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KMID : 0043319950180050346
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Archives of Pharmacal Research
1995 Volume.18 No. 5 p.346 ~ p.350
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Effects of Ethylcholine Aziridinium, Scopolamine and Mor-phine on Learning Behaviors in Morris Sater Maze
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Lim Dong-Koo
Wee Sun-Mee
Ma Young
Yi Eun-Young
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Abstract
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To assess the behavior of the various chemicals, such as ethylcholine axiridinium (AF54A), scopolamine and morphine, the chemicals were administered into eitheer rat or mice. And water maze tests were performed before and during drug administration. In AF64A-treated groups (3 nmol/each ventricle), the latencies to escape was significantly increased in both of the pretraining-and posttraining groups. In scopolamine-treatment (2mg/kg, sc) to the pretrained group, the latency to escape was significantly shortened after the acute administration of scopolamine. However in subscute treatment group with scopolamine, the latency to escape was significantly increased. In morphine-treated groups (10 mg/kg, ip), the subacute treatmment with morphine, the latency to escape was not ahcnged. The results indicate that each chemical induces the learning impariment. However the chrmical-induced learning impairment may have different characteristics upon the exposed chemical. Also the results suggest that both the motivation and the retrieval of memory might be impaired by AF64A.
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KEYWORD
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Ethylcholine aziridinium, Scopolamine, Morphine, Morris water maze
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